Picking the 5 Best 5-HTP Supplements

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5-HTP is a potent naturally occurring amino acid derived from plants. It boosts the serotonin levels and has a positive impact on sleep, mood, and pain. Due to its powerful therapeutic properties, studies have shown that 5-HTP can help treat fibromyalgia, depression, insomnia, chronic headaches, and binge eating (caused by anxiety).

It has a quick and effective impact on the central nervous system because of how well-absorbed it is. In fact, around 70% of it ends up in the bloodstream. It could prove useful for soothing tension from PMS (premenstrual syndrome), ADHD (attention deficit-hyperactivity disorder), Parkinson’s, or seizures.

Even though the 5-HTP has been proven by research to be an effective supplement, people have trouble deciding which one to pick. Too many such supplements are available today. You need one that is efficient and safe to use. Here, we have listed all the top-quality 5-HTP supplements you can come by.

Top 5 5-HTP Products

Decreased serotonin levels have been associated with anxiety, sudden weight gain, depression, sleep disorders, and overall health issues. Supplements that can increase the serotonin levels have been getting more and more popular.

However, not every brand offers a quality product you can depend on. We have decided to narrow down the search for you and filter products of great value that offer excellent results. They are manufactured with carefully selected ingredients and have undergone a series of tests. Let’s take a look at the best 5-HTP supplements you can buy online.

1. Dr.Emil Nutrition 5-HTP Plus Serotonin

Dr Emil Nutrition 5 Htp Plus

This is one of the most popular 5-HTP supplements you can find online. The brand has been manufacturing distinctive supplements for years. The company relies on cutting-edge techniques and clinical testing to produce all its products. The Dr. Emil Nutrition supplement contains two important ingredients, SAMe and L Tryptophan. Both of these ingredients positively affect the 5-HTP conversion.

The key ingredient to this formula is Vitamin B6. It contains only natural vitamins, herbal extracts, and minerals. It’s free of additives, gluten, or GMOs. It’s FDA registered and manufactured in the USA.


  • FDA- registered
  • Tested
  • No harmful additives
  • GMO-free
  • Gluten-Free
  • Manufactured in a GMP certified lab


  • Not recommended for a sensitive stomach
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2. Pure Encapsulations 5-HTP

Pure Encapsulations 5 Htp

Pure Encapsulations 5-HTP is made only with the purest ingredients carefully selected and tested. But, most importantly, it is GMO-free, gluten-free, and a hypoallergenic supplement. Hypoallergenic products deliver predictable results to benefit every individual, even those who are the most sensitive to supplements. The product is manufactured by a reputable company that has been around for years. All their supplements are research-based and high-quality products.


  • Top-quality product
  • Natural ingredients
  • GMO-free
  • Hypoallergenic
  • Gluten-free
  • No Artificial Sweeteners


  • If you use it for an extended period, your system could get used to it, and it won’t work anymore.
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3. Thorne Research 5-HTP

Thorne Research 5htp

The Thorne research-5-HTP is rich with Vitamin B6. This vitamin is very versatile, performing in different functions in the body. In fact, it is involved in more than 100 enzyme reactions.

These supplements are made of the purest ingredients available. Anyone with major allergies can freely use it. No soy, fish, dairy, shellfish, eggs, peanuts, or nuts. You can consume it with meals without affecting its potency. It has undergone four different rounds of testing to ensure top-quality and safety.


  • 100% clean supplement
  • Made of the purest ingredients
  • Gluten-free
  • No allergens (like peanut, tree nuts, or eggs)
  • Excellent absorption
  • Top-quality formula


  • It leaves a metallic aftertaste.
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4. Toniiq Ultra High Strength 5-HTP

Toniiq 5 Htp

Toniiq 5-HTP capsules have an excellent quality formula with superior potency. The key ingredient is Griffonia seed extract, which provides a 99% 5-HTP. This 5-HTP is of the purest quality. The ingredients are cultivated on local farms in Ghana. The product is then manufactured in the USA. It has a much higher concentration of the amino acid than other supplements, which provides higher absorption and boosts effectiveness. Every batch is carefully tested and GMP-certified.


  • Vegan-friendly
  • No Preservatives
  • Gluten-Free
  • GMP-certified
  • 99% STD Purity
  • Increased potency


  • It can make you feel sleepy.
  • Not recommended for a sensitive stomach.
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5. Arazo Nutrition 5-HTP

Arazo Nutrition 5 Htp

The Arazo nutrition supplement offers a potent formula made in a GMP and FDA Certified facility. Aside from the 5-HTP, it contains Calcium carbonate.


  • Made in a GMP and FDA Certified Facility
  • Potent ingredients
  • Natural source of 5-HTP


  • Not recommended for a sensitive stomach.
Get it on Amazon

How We Selected These Products

Much research is necessary to confirm that a supplement can provide the benefits it offers. To choose the ideal 5-HTP supplement, you shouldn’t go for a random product and hope for the best.

Before we select any supplements, we consider four important factors. These factors are company reputation, value, concentration, and ingredients.

Company Reputation

The most important thing when selecting a supplement is to know the name of the company that manufactures it. Companies must be certified and experienced in their field to be included on this list. All the products must be tested, and a good reputation is also crucial.


It’s important not to spend too much on a single supplement. Pick the price that suits you best. When purchasing supplements, the cheapest option is not always the smartest. The price often depends on the quality of the ingredients. Those who offer better results often come at a higher price. Consider how much you are willing to spend and how much each serving will cost you. Take a look at the concentration and the dosage to determine its value. If you plan to use it for an extended period, invest in a bigger dosage. For tryouts, the smallest packages will suffice.


The purity of the supplement shouldn’t be ignored. You shouldn’t buy one with a higher dosage and poor concentration. Instead, you should go for a low dosage and high concentration. The potency of the extracts used in the supplement is determined by the concentration level. The higher the concentration, the better the formula.


The key component of every supplement is the ingredients. All of these supplements contain beneficial ingredients that can increase serotonin levels. They all have top-quality compounds with potent properties. 100 to 200mg of 5-HTP is the standard size. Some contain plant extracts, others are rich in vitamins, but they all have a positive effect on the nervous system. If you are looking for a supplement that can benefit certain problems, it’s crucial to pick the right ingredients that suit your needs. Another important factor is the allergy. Knowing the ingredients can help people avoid allergens or potential health risks.

Possible Side Effects

If you don’t pay attention to the dosage or haven’t consulted a doctor before taking supplements, side effects are possible. With proper dosage, side effects are minimal. That being said, it’s possible to experience gas, bloating, heartburn, stomach problems, or nausea.

5-HTP supplements can interact with some medications, particularly antidepressants and SSRIs. If you are taking any drugs or undergoing specific treatments, you must consult with your doctor before adding 5-HTP supplements to your diet.

In the extreme, but rare cases, serious side effects can occur like vomiting, muscle issues, or problems during intercourse. But, these often vary from person to person. If you experience any, ask for a medical evaluation or stop taking supplements immediately.

Final Thoughts

5-HTP supplements may be helpful for people suffering from sleep disorders, eating disorders, depression, anxiety, or other similar issues.

This amino acid is available in plenty of natural herbal or dietary supplements. Because of the large variety available on the market, we have filtered through all the options and picked 5 of the best-researched and top-quality products on this list.

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